Investigation of Association Between KISS1R rs397515615 Polymorphism with Idiopathic Male Infertility

Infertility referes to the inability of a couple to conceive over an average period of one year with unprotected sexual intercourse. In mammals, Fertility is initiated at puberty by the pulsatile secretion of gonadotrophin releasing hormone (GnRH). Kisspeptin (product of Kiss1 gene) and its receptor (KISS1R) are as vital upstream regulatorsin integrating of central and peripheral signals with GnRH release. In this paper, we studied an association between polymorphism rs 397515615 in the KISS1R gene with idiopathic male infertility.
Material and In this research, we were evaluated a total of 50 men with idiopathic infertility and 50 healthy men (control group). AS-PCR method was applied for determination of the codon polymorphism. Also we used chi-square (χ2) test to study of an association between genotype and allele frequencies in cases and control groups.
The results showed that the genotypic frequencies between two groups revealed a significant difference between the patients and healthy (P=0.02), while Allele distribution (G/-) between case and control groups was not significant (P=0.20).
The results of this study show that the polymorphism of rs 397515615 KISS1R gene probably associated with idiopathic infertility in men. However, further studies with larger and different geographical population are needed to confirm the results.