Cardiovascular effects of nitrergic system of the pedunculopon-tine tegmental nucleus in anesthetized rats
Author(s):
Abstract:
Objective(s)
Nitric oxide (NO) is an important neurotransmitter in central nervous system involved in central cardiovascular regulation. The presence of NO in the pedunculopontine tegmental (PPT) nucleus has been shown, but its cardiovascular effect has not been determined. In the present study, the cardiovascular effect of NO in the PPT nucleus was evaluated.Materials And Methods
After induction of anesthesia, a polyethylene catheter (PE-50) filled with heparinized saline inserted into the femoral artery, and the blood pressure (BP) and heart rate (HR) were continuously recorded. Animals were then placed in a stereotaxic apparatus and maximum changes of mean arterial pressure (∆MAP) and heart rate (∆HR) after microinjection of two doses of NG-nitro-L-arginine methyl ester (L-NAME, 30 and 90 nmol), L-arginine (L-Arg 10 and 50 nmol) and sodium nitroprusside (SNP, 9 and 27 nmol) into the PPT were provided and compared with control group (One-way ANOVA).Results
Both doses of L-NAME significantly increased ∆MAP compared to control (PPConclusion
Our results show an inhibitory effect of the nitrergic system of the PPT on central cardiovascular system. Keywords:
Language:
English
Published:
Iranian Journal of Basic Medical Sciences, Volume:20 Issue: 7, Jul 2017
Pages:
776 to 782
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