Effects of Hydro- alcoholic Extract of Falcaria Vulgaris on Pancreas Tissue in Streptozotocin-induced Diabetic Rats

Diabetes, as a chronic disease, is the third leading cause of death in developing countries. Hyperglycemia and oxidative stress have been recognized as the main factors involved in pathogenesis of diabetes. On the other hand, the antioxidant system is the first defense mechanism of body against oxidative stress. Falcaria Vulgaris possesses hypoglycemic and antioxidant effects. This study surveyed the effects of different doses of Falcaria vulgaris extract (50,100,150 mg/kg) on histological changes of Langerhans islets andserum insulin, nitric oxide and glucose levels.
A total of 64 male Wistar rats were divided into 8 groups (control, diabetic with STZ, treatment with Falcaria Vulgaris (50,100,150 mg/kg) and diabetic treated with Falcaria Vulgaris) (50,100,150 mg/kg). Data were analyzed by one-way ANOVA, and p value Falcaria Vulgaris extract (100 and 150 mg/kg) significantly decreased serum glucose level (p F. vulgaris can improve insulin secretion and serum glucose levels in an animal model of STZ induced diabetes, possibly by reducing nitric oxide production and preventing pancreatic tissue oxidative damage.