The Antioxidant Activity of Palmitoleic Acid on the Oxidative Stress Parameters of Palmitic Acid in Adult Rat Cardiomyocytes

Many researches have focused on reducing the deleterious effects of oxidative stress in biological systems. The present study investigated the effect of palmitoleic acid on the oxidative stress parameters induced by palmitic acid on cardiomyocytes.
Rat cardiomyocytes were treated with 0.5 mM palmitate, palmitoleate,
and palmitate palmitoleate, or remained as control. Total antioxidant capacity (TAC) and Malondialdehyde (MDA) values were measured in both the cells and the media at 24h and 48h intervals.
While cellular TAC values decreased in the palmitic acid group compared to the control group (24%) at 48h time point (P In conclusion, the harmful effects of the oxidative stress induced by palmitate would be diminished by palmitoleate in the rat cardiomyocytes.