The comparison effect between Haloperidol and Midazolam & plassebo in Delirium treatment on adult male rat based on behavioural changes

Delirium is change in consciousness and ability to focus and attention . it is reducing costs and increasing the time patients stay in hospital . While sedative and hypnotic drugs reduce pain and anxiety , but according to sources , it is one of the risk factors of delirium . Haloperidol because of low anticholinergic activity and low drug interactions and metabolites have more therapeutic use.
this search is experimental method,90 rats were studied . Biperiden 40 mg / kg to 42 mice and LPS 50µg/kg was administered to 42 mice . Delirium confirmed by studying the behavior of mice for 60 minutes. The control group consisted of 6 mice . Compare the dose and effect of haloperidol and midazolam on treatment of delirium in treatment groups by studying the behavior of delirium in 30 minutes after injection were studied (p≤0.01in haloperidol group0.2mg/kg compromise withmidazolam0.5mg/kgand1mg/kg) . Kruskal-Wallis test and man_u_witney post test were analized.
findings are: created deliriumin this study was: 16% hyperactive , 20% hypoactive and other were mixed . Both drugs haloperidol and midazolam were effective on hyperactive standards of behavior((p≤ 0.05in haloperidol group0.1mg/kg and midazolam 0.25mg/kg) . Haloperidol in low doses were effective on hypoactive delirium and 0.5 mg / kg dosage had no significant effect . Midazolam in this case was significant on at low doses but 1mg / kg dosage worse this situation .
The findings of this study shows the importance of early diagnosis and treatment of delirium especially hypoactive type because of improper treatment worsens (high-dose midazolam) prognosis patient's and condition