Effect of Probiotics on Serum Bilirubin Level in Term Neonates with Jaundice; A Randomized Clinical Trial
Author(s):
Abstract:
BackgroundIn recent years, tendency to use drugs has been increasing in the treatment of neonatal jaundice. Several drugs have been used since then, but the effect of probiotics on serum bilirubin level (SBL) is not so clear. This study was conducted to evaluate the effect of probiotics on SBL and the duration of phototherapy in term neonates with hyperbilirubinemia.
ConclusionOral probiotics in neonates with jaundice has no significant effect on SBL and the duration of phototherapy. Further studies are needed to with longer time follow-up.
Materials And Methods
In this randomized clinical trial, we studied 150 term neonate with jaundice hospitalized for phototherapy in Amirkola Childrens Hospital, Babol- Iran, during October 5, 2016 till May 19, 2017. Eligible neonates were randomly divided into two; intervention (n=75), and control (n=75) groups. Both groups received standard conventional phototherapy, but the intervention group received 10 drop/day of probiotics (Pedilact Zisttakhmir. Co. Iran), until hospital discharge. The outcome variables were SBL and the duration of phototherapy. The data was analyzed by SPSS 22.0 and the P Results
The mean SBL before intervention in the intervention and control groups was 16 ±1. 9 and 16.9±1.9 mg/dl, respectively (P>0.05.After 24, 48 and 72hours it decreased to 13.73±1.72, 10.92±1.87 and 10.25±1.32 in the intervention and 13.66±1.91, 11.01±1.69 and10.09 ±1.38 in the control groups, respectively but comparison of the amount of SBL reduction between the two groups was not significant (P>0.05). The duration of phototherapy in the intervention group and the control group was 3.61±1.17 days and 3.72±1.18 days respectively (P>0.05).ConclusionOral probiotics in neonates with jaundice has no significant effect on SBL and the duration of phototherapy. Further studies are needed to with longer time follow-up.
Keywords:
Bilirubin , Jaundice , Newborn , Phototherapy , Probiotic
Language:
English
Published:
International Journal of Pediatrics, Volume:5 Issue: 46, Oct 2017
Pages:
5953 to 5958
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