Comparison of Topical effect of Mentha piperita and Rosmarinus Officinalis Essential Oils on Infected Wound whit Candida Albicans in Rat

Wound infections caused by Candida albicans has grown substantially in recent years. Development of drug resistance led to the use of biological materials may be considered as an alternative solution. Studies show that Mentha piperita and Rosmarinus officinalis contains flavonoids and menthol and hence they has antibacterial properties. We used sixty male Wistar rats (weight 195-205 g). One square surgical wound with dimensions of 1/5×1/5 cm were performed on the back of each animal and immediately became infected whit 0.1 ml of 1/5×107 CFU Candida albicans suspension. Then the rats were divided into 4 groups (control, placebo and Menthe piperita 3% ointment and Rosmarinus officinalis 3% ointment) each with 15 rats and randomly distributed into 5 subgroups each whit 3 rats (sample groups on different days). Wound healing activity was performed by histological qualitative studies and yeast counts on the end of 4th, 8th, 12th, 16th and 20th days after surgery. Edema rate in treated groups in comparison with control and placebo groups significantly decreased (p