Study of PAI-1 -675 4G/5G Polymorphism among patients with breast cancer from North West of Iran

Previous studies have shown the association of genetic factors such as PAI-1 4G/5G polymorphism with susceptibility to breast cancer patients. The aim of this study was to investigate the effect of this polymorphism in breast cancer patients from North West of Iran.
160 breast cancer patients and 160 healthy individuals were selected. Peripheral blood-DNA samples were taken and used for PCR amplification using the allele specific primers.
Based on molecular studies, all patients and control group were divided into three genotypes 4G/4G, 4G/5G and 5G/5G. Genotype distribution between patients (11.25%, 71.25% and 17.50%, respectively) and controls (10.62%, 71.87% and 17.50%, respectively). Additionally, the frequencies of the 4G and 5G alleles between patients (46.87% and 53.12%, respectively) and control group (46.56% and 53.43%, respectively).
The genotypic and allelic frequencies of PAI-1 4G/5G polymorphism showed no significant difference between breast cancer patients and control individuals in this cohort.