Improvement of spatial memory of male parkinsonian rats after treatment with adipose stem cells and rosemary leaf extract

Due to the neuroprotective effect of rosemary extract, this study aimed at examining the effect of co-treatment of adipose stem cells transplantation and the extract on memory disability of parkinsonian rats.
In this experimental study, male parkinsonian rats were prepared by bilateral injection of 6-OHDA. The sham group was injected normal saline into the substantia nigra. The extract駧抺 group was gavaged with the extract 14 days before until 8 weeks after the injury, and the medium was intravenously injected. The extract燩 group was orally gavaged with the extract and the cells were injected. Morris water maze training was conducted one week before and after the lesion and also a retrieval test was performed 4 and 8 weeks after the lesion.
There was no significant difference in distance moved and escape latency at training days, before the injury, between the groups. However, a week after the injury, learning ability in lesioned animals was significantly decreased as compared to the sham group (P The cell therapy accompanied with orally administration of the rosemary extract can improve memory deficit in Parkinson’s disease.