Antihyperlipidemic Effect of Different Fractions Obtained from Teucrium polium Hydroalcoholic Extract in Rats

This study was aimed to screen the antihyperlipidemic effect of different fractions of Teucrium polium to obtain the most effcient herbal fraction for isolation of bioactive constituents responsible for hypolipidemic activity.
Chloroform, butanol, and aqueous fractions were obtained from hydroalcoholic extract of T. polium aerial parts using partitioning process. To induce hyperlipidemia, dexamethasone (Dex) was injected 10 mg/kg/day (s.c.) for 8 days. In the test groups, animals received 50, 100 and 150 mg/kg of T. polium hydroalcoholic extract and different fractions orally simultaneously with Dex. Serum lipid profle and hepatic marker enzymes were evaluated using biochemical kits.
All treatments, especially chloroform and aqueous fractions, reversed serum lipid markers in hyperlipidemic rats. Maximum reduction in triglyceride (60.2%, P This study showed strong antihyperlipidemic effect of various fractions derived from hydroalcoholic extract of T. polium.Chloroform and aqueous fractions may be worthy candidates for isolation of bioactive hypolipidemic constituents. However, possible hepatotoxicity should be considered for clinical application.