Effect of Interval Training Intensity on ANP and BNP Gene Expression Levels after Myocardial Infarction

Myocardial infarction is the cell death in part of the myocardial during an ischemia. ANP and BNP values are known as strong markers of myocardial infarction and severity of disease. So, this study was conducted to evaluate the effect of precedent of six weeks high intensity interval training and light intensity interval training on the ANP and BNP gene expression in rats after myocardial infarction. For this purpose, 18 Wistar male rats with 10 weeks old and average weight 250-300gr are placed in two experimental groups, high intensity interval training (85-90% VO2max) and light intensity interval training (55-60% VO2max) and a control group (without any training). Genes expression was investigated with qRT-PCR and data were analyzed by the SPSS 18 with T test and ANOVA (α≤0.05). The findings of present study showed that six weeks high intensity interval training decreased insignificantly BNP and ANP but their reduction was significant during light intensity interval training group than the control group (respectively P=0.067 and P≤0.475). this reduction in light intensity interval training group was significantly more than high intensity interval training group (ANP (P=0.005) and BNP (P=0.001)). In general, six weeks of high intensity interval training and light intensity interval training could reduce cardiac hormones levels compared to control group after myocardial infarction.