Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats

Introdution The purpose of this study was investigating the effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats.
24 male Wistar rats were randomly assigned to three groups of eight, including diabetic group with endurance exercise (D-E), diabetic (D) and healthy control groups (Con). After induction of diabetic rats by injection streptozotocin was administered intraperitoneal , endurance exercise was applied for eight weeks, three sessions pre week in diabetic rats. Exercise intensity was equal to a speed of 21-25 m / min. The relative expression of CGI-58 and ATGL protein was measured with western blot technique and serum insulin and glucose levels were measured with a specialized kit. One-way ANOVA test was performed using SPSS-20 software and at a significance level less than 5%.
Results showed that ATGL and CGI-58 values were significantly different between the three groups (p It seems that CGI-58 play a vital role in activating lipolysis by ATGL and increasing in CGI-58 leads to an increase in ATGL and ultimately leads to increased levels of intramuscular triglyceride oxidation and improved insulin resistance.