The Effect of Indomethacin on the Calcium Phosphate/polymer Light-Cured Nanobiocomposites ‎Behavior

In this study, a new bioactive and light-cure polymeric calcium phosphate nanocomposite containing a powder phase consisting of pure TetraCalciumPhosphate was synthesized by solid state sintering. By using indomethacin, a non-steroidal anti-inflammatory drug, and a liquid phase including polyhydroxy-based resin, Ethyl Methacrylate was prepared and evaluated after curing with the high-intensity blue light. Phase changes in the cement composition after soaking in phosphate buffered saline (PBS) were investigated using X-ray diffraction (XRD). Morever, changes in the chemical groups in the cement and the microstructure of the cement after soaking in the PBS were investigated by Fourier transform spectroscopy (FTIR) and electronscanning microscopic (SEM) images, respectively. XRD patterns and SEM images showed that after soaking the samples in. the PBS solution, a new calcium phosphate phase with a shape like needle and polka appeared on the surface, which was formed more in the drug-containing sample at a concentration of 5% wt. of these nanostructures. Other results also showed that with the passage of time, the structural degradation in the PBS was due to the conversion of the initial phases to the calcium phosphate phase (apatite). Also, the results of the mechanical strength test of polymeric cement samples containing the drugshowed that the mean compressive strength of the samples after the fixation was about 56 MPa, and it was decreased by 26 MPa with continuous immersion after 21 days.