Effects of Combined Exercises beside Consumption of Omega-3, L-Carnitine Supplements on the Serum Level of Irisin, Resistance Insulin, Profile Lipid of Type 2 Diabetic Women Ali Hassani (Ph.D.)1*, Masoume Ghorbani (M.Sc.)2

Determining the effect of combined exercises along with the consumption of omega-3 and L-carnitine on the serum level of Irisin, resistance insulin, and profile lipid of type 2 diabetic women.
In this clinical trial study, 58 female volunteer with type 2 diabetes, were randomly divided into 6 groups of 10 persons: 1. exercise placebo; 2. exercise omega-3 supplement; 3. exercise L-carnitine supplement; 4. exercise L-carnitine omega-3 supplements; 5. omega-3 L-carnitine supplements; and 6. control group. Combined Exercises (8 week, 3 sessions per week) included a 30 minutes aerobic exercise of running on a treadmill, and 30-40 minutes resistance exercise of circular. The omega-3 group consumed 2 capsules (each 1,000 mg) of omega-3 each day, and the L-carnitine group consumed 500 mg L-carnitine each day. The consent forms and the health questionnaires and physical activity (PAR-Q) were completed by the participants. Results were analyzed by SPSS.
The findings were evaluated among women with a mean age of 52.7±6.1 (years). Serum level of irisin in s was significantly increased in group 2 (P=0.02) and 4 (P=0.04). A significant HDL increase was observed in groups 4 and 5 (P=0.005), and a significant TG decrease was observed in groups 2 (P=0.01), 4 (P=0.03), and 5 (P=0.05). Resistance insulin had a significant decrease in group 2 and 5 (P=0.04), (P=0.01).
Results showed that exercise omega-3 supplement, and exercise L- carnitine omega-3 supplements were more appropriate stimuli than other groups to increase Irisin level, and reduce the diabetes risk.