Evaluating the effect of pentazocine and dextromethorphan on progesterone induced depression in female mice

Message:
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Aims
Progesterone is a female reproductive hormone. Increasing progesterone levels during menstruation or taking synthetic progesterone in oral contraceptives causes some depression in some women. Sigma receptors are considered as new targets in depression medication. Progesterone other than hormonal effects is a neuro-steroid and is an antagonist to sigma receptors. So, the aim of the current study was to investigate the effect of co-concomitant use of progesterone with sigma agonist drugs, dextromethorphan or pentazocine on depression test.
Methods
This research is a basic- applied study. Experiments were performed on female mice weighing 25-30 g. The forced swimming test was used to investigate depression. Progesterone 10 mg/kg along with dextromethorphan HBr 30 mg/kg, or pentazocine 2.5 mg/kg were administered on the first day and 30 min before the FST on the second day. Data were analyzed using One-way ANOVA and Tukey tests.
Results
Progesterone led to an increase in the immobility time (over 3 minutes) in mice, which is a criterion for animal depression (P
Conclusion
Since depression caused by progesterone is resolved by Sigma agonists, Sigma receptors are responsible for depression caused by high doses of progesterone. So, these agonists can be considered as an effective antidepressant in progesterone medications with high dose.
Language:
Persian
Published:
Journal of Shahrekord University of Medical Sciences, Volume:20 Issue: 2, 2018
Pages:
100 to 108
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