Investigating the Effect of 8 Weeks of Aerobic Exercise in Combination with Hydroalcoholic Extract of Cinnamon on Serum Visfatin and Vaspin in Insulin-Resistant Rats

Visfatin and Vaspin are two adipokines playing a role in increasing or decreasing insulin resistance. The present study aimed at investigating the effect of 8 weeks of aerobic exercise in combination with cinnamon extract on visfatin and vaspin in insulin-resistant rats.
Thirty-six Wistar male rats were divided into four groups: control (N=9), aerobic exercise (N=9), cinnamon extract (N=9), and aerobic exercise cinnamon extract (N=9). Insulin resistance status was induced by %10 fructose solutions during 5 weeks. The exercise groups were subjected to a 5-day per week aerobic exercise program (with 75-80% VO2max) for 8 weeks. 200 mL/kgBw/day cinnamon extract was injected to the rats in the cinnamon extract groups. The Data were analyzed using one-way ANOVA and the significance level was set at p The results showed that aerobic exercise with and without cinnamon extract significantly decreased the serum visfatin, insulin and insulin resistance (P The results of the present study indicated that aerobic exercise may improve insulin resistance in insulin-resistant rats changing the levels of serum visfatin and vaspin. However, it can have a greater effect on visfatin when combined with cinnamon extract.