Investigating the Effect of Aerobic training and Sesamin Supplementation on Serum Levels of Tumor Necrosis Factor-Alpha and C-Reactive Protein in Trained Men

One of the ways to cope with the adverse effects of inflammation caused by exercise is the use of oral anti-inflammatory supplements. Among these, Sesamin is one of the most effective nutritional supplements used to reduce the inflammatory-oxidative damage caused by various types of exercises.
In this quasi-experimental study, 40 trained men aged 20-25 years were selected through convenience sampling and after obtaining informed written consents, the participants were randomly assigned to four groups: placebo (10), aerobic training (10), aerobic training sesamin (10) and sesamin (10). Serum levels of tumor necrosis factor-alpha and C-reactive protein were measured by Elisa kits. The data were analyzed by t-test, ANOVA and Tukey's post-hoc test using SPSS 20.
The results of ANOVA showed that serum levels of tumor necrosis factor-alpha in the supplementation aerobic training and supplementation groups were significantly different from those in the other groups (respectively, p=0.022 and p=0.001) and the same was the case for serum level of C-reactive protein in the supplementation aerobic training group (p Aerobic training in combination with Sesamin supplementation is an effective method to improve the health of trained men. In addition, combining supplementation with aerobic training can increase some of the beneficial effects of training over a 10-week period and decrease inflammation caused by training.