The effects of mid and long-term endurance exercise on heart angiogenesis and oxidative stress
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Objective(s)
Long-term, irregular endurance exercise may result in disturbance to the angiogenesis of heart muscles and blood supply. The aim of the present study is to evaluate the effects of mid- and long-term endurance exercise on the process of angiogenesis.Materials And Methods
Eighteen male Wister rats of 220±10 g, were randomly assigned to three groups of 6 rats including: Control, Mid, and Long Group. After the training sessions, the rats were weighed and sacrificed.Results
In comparison to the Control Group, the both groups, indicated remarkable increase in the weight of heart and significantly higher serum LDH and CK activity (PConclusion
In this study, higher oxidative status and upper angiogenic gene expression with higher VEGF-B, MEF-2c, and MMP-2 and lower ANGPT-1 and HDAC4 were traced as effects of long-term endurance exercise. These results point to the dis-regulation of blood supply in the presence of angiogenesis resulting from long-term exercise.Keywords:
Angiopoietin , 1 , Endurance Exercise , HDAC4 , MMP , 2 , VEGF , B
Language:
English
Published:
Iranian Journal of Basic Medical Sciences, Volume:21 Issue: 8, Aug 2018
Pages:
800 to 805
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