The Effect of Aspirin and Ibuprofen on the Proliferation of Cervical Cancer Cells (HeLa) Compared to Non-Cancerous Cells (HEK 293) in Cell Culture Medium
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background And Objectives
Studies have shown that anti-inflammatory drugs can affect growth and development of cancer. This study was carried out to determine the effects of aspirin and ibuprofen on viability of cervical cancer cells (HeLa) compared to non-cancerous cells (HEK 293).Methods
In this laboratory-experimental study, cervical cancer cells (HeLa) and non-cancerous cells (HEK 293), were randomly divided into control group and groups exposed to aspirin and ibuprofen (at doses of 0.01, 0.1, 1, and 10mg/ml. Twenty-four hours after exposure to the drugs, the viability of cells, was measured using MTT assay method. Data were analyzed using between group analysis of variance statistical method.Results
The viability of HeLa cells significantly decreased when exposed to aspirin at doses of 0.01, 0.1, 1, and 10mg/ml (pConclusion
The results of this study showed that aspirin and ibuprofen can have cytotoxic effect on cervical cancer cells; while have no significant cytotoxic effects on non-cancerous cells.Keywords:
Aspirin , Ibuprofen , Viability , HeLa Cells , HEK293 Cells
Language:
Persian
Published:
Qom University of Medical Sciences Journal, Volume:12 Issue: 5, 2018
Pages:
16 to 24
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