Fabrication and Evaluation of β-Cyclodextrin Modified Nano Zeolite as Carrier for Curcumin

In this study, nano ZSM-5 zeolite was synthesized in the absence of organic template by hydrothermal method. In the next step for loading of curcumin in nano carrier was selected methanol reflux method. Characterization of nanoparticles was performed by X-ray diffraction, Scanning electron microscope, Fourier transform infrared spectroscopy and Thermal gravimetric analysis. Efficiency of loading and drug release was determined by UV-Vis spectrophotometry. Scanning electron microscopy showed that smallest of particle size is approximately 44 nm. Fourier transform infrared spectrometer and Thermal gravimetric analysis confirmed synthesis and functionalization of nano zeolite with cyclodextrin as well as complex formation of curcumin and modified nano zeolite. The drug loading on the surface of the nanoparticles in optimal conditions was 95. and efficiency of drug release was evaluated 43 in pH 7.4 and 61 in pH5.5. This indicates that the performance of the drug delivery system in tumor tissues is higher than healthy tissues. The synthesized nanocarrier is an appropriate approach for the delivery of hydrophobic drugs to the target tissue such as curcumin drug that has sub-optimal pharmacokinetics and poor bioavailability.