Comparison the Effect of Ginger Hydroalcoholic Extract with Treadmill Walking on Tissue and Levels of Hepatic Transaminases Changes in Rat with Non-Alcoholic Fatty Liver Disease

Ginger has antioxidant properties that improve oxidative indices. The use of high-fat diet is one of the reasons for the prevalence of liver disease. Therefore, the aim of the present study was to investigate the effect of ginger and treadmill walking on serum levels of hepatic enzymes and tissue changes induced by high-fat diet in mature male rats.
In this experimental study, 56 mature male rats were divided into control (without treatment), control (treatment with high-fat diet 10 ml/kg) and 5 experimental groups receiving high-fat diet (10 ml/kg) with 200 and 100 mg/kg ginger extract alone and with treadmill walking. Ginger was administered as gavage in 28 consecutive days. At the end, after anesthetizing the animals and collecting blood from their hearts the AST, ALT and ALP enzymes were measured, and their liver was removed and after preparing the tissue sections, the results of hepatic enzymes measurements were analyzed by ANOVA and Duncan tests and P≤0.05 was considered significant.
The results showed that high-fat diet increased AST, ALT and ALP enzymes and tissue damage of the liver compared to the control group at the level of p The results showed that high-fat diet increased the levels of ALT, AST and ALP, and hepatic tissue damage. Treadmill walking and ginger extract alone and together reduce ALT, AST and ALP and improve the hepatic tissue structure.