Reduction of Tumor Necrosis Factor Alpha and Nuclear Factor- Kappa B Gene Expression in Lung Tissue of Rats After a Period of Swimming Training

Considering the important role of inflammation in pulmonary disorders the purpose of this study was to investigate the effect of a period of swimming training on Tumor necrosis factor alpha (TNF-α)and Nuclear factor- kappa B (NF-κB) gene expression in lung tissue of wistar rats. Twenty wistar rats of five weeks ages with the weight range of 102±23 g randomly divided into control (n=10) and swimming training groups (n=10). The training protocol included three months of swimming (5 times per week) which begun from 25 minutes in the first week (with the water flow intensity of 4 liters per minute) and reached to 60 minutes (with the water flow intensity of 10 liters per minute) at the final week. Quantitative Real-Time PCR used for detecting and quantifying expression profiles of TNF-αand NF-κB genes in the lung tissue of rats. Kolmogorov-Smirnov test was used to test the normality of data distribution and Independent t test was used to determine the between group differences (α