Effect of supplementation of vitamin D, C and E on the lung spirometry and plethysmography in Idiopathic Pulmonary Fibrosis patients

Idiopathic pulmonary fibrosis is one of the most important chronic respiratory diseases. One of the causes of its occurrence and exacerbation is imbalance in the antioxidant and inflammatory systems. The aim of this study was to evaluate the effect of supplementation of these vitamins on functional lung tests in adults with pulmonary fibrosis.
33 patients participated in this quazi clinical trial for 3 months and supplemented with E, C and D vitamins with 200 IU, 250 mg and 50000IU doses, respectively. At the beginning and end of study anthropometric measurements and Body Mas Index (BMI), 24-hour recall, physical activity, sun exposure and Saint George questionnaires were investigated. Moreover, lung function factors were measured by using spirometry and plethysmography. Data were analyzed by SPSS version 21 and paired t-test statistical test.
The results obtained from spirometry and plethysmography tests represent a significant increase in percent of FEV1 (p= 0.016), IRV (p= 0.001), RV (p= 0.002) and TLC (p= 0.003). But there was no significant difference in percentage of FVC, VC, FEV1/FVC and ERV (p> 0.05). The rates of respiratory function have significant improvement according to the Saint George questionnaire. Also, there was no significant difference in confounding variables.
It seems that taking 3 months of D, C and E vitamins in patients with lung fibrosis has a significant effect on respiratory function