The Effect of Retinoic Acid on Uterine Tissue and Estradiol, Progesterone Hormones in Female Adult BALB/c Mice

Retinoic acid is recognized as a regulator of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was done to investigate the effect of retinoic acid on the uterine tissue and estradiol and progesterone hormones in female adult BALB/c mice.
Material & In this study after determining the appropriate dose of retinoic acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg.b.w (Group III), control group (non- injection) and sham (distilled water injection). ANOVA analysis and Duncan test were applied to compare the means with significance level (P˂0.05) and (P˂0.001).
Uterine tissue studies indicated an increase in overall thickness of the uterus (endometrium, myometrium, perimeterum) (P It can be concluded that retinoic acid has damaging effect on the uterus tissue and sexual hormones, and its use especially in female should be by awareness and under physician supervision.