The Comparison of the effect of Origanum vulgar aqueous extract and Vitamin C on the control of Cadmium Chloride damage in testicular tissue in Male Rats

Regarding the toxic and oxidative effects of cadmium on male reproductive system and controlling importan, the aim of this study was to compare the effect of Origanum vulgar aqueous extract and vitamin C on cadmium chloride damage in testicular tissue. In experimental interventional study used 30 wistar male rat. The control received Cadmium 2 mg/kg of single dose intraperitoneal, T1 group received cadmium with vitamin C 250 mg/kg. T2, T3 and T4 groups received cadmium and aqueous extract of Marjoram at 125, 250 and 500 mg/kg, respectively for 10 days intraperotonealy. At the end of the period, the animals were weighed. Serum antioxidant level and malondialdehyde in testis tissue were measured. In addition, after staining were counted calls in testicular tissue. Findings: The highest concentration of MDA was observed in the control group at 1.4 ± 0.018 and the lowest in the T4 at 93.03 ± 0.30 μmol/ml. In association with TCA, the lowest in control was 796.41 ± 40.76 and the highest in T4 group was 1198.91 ± 51.45 μmol/ml. There was no statistically significant difference in the concentration of MDA and TCA between T1 and T3 groups (P=0.076). However, the mean of testicular tissue cells (sertoli, spermatogonia, spermatocytes and laydic) in T3 was the highest and lowest mean in control group and the difference was significant (P=0.048). Marjoram aqueous extract in controlling oxidative stress damage in the same dose 250 mg/kg has a better performance than vitamin C.