Synthesis, characterization and sustained release of celecoxib from poly(lactic acid) nanofiber

In this study, biodegradable/biocompatible nanofiber electrospun mats of polylactic acid (PLA), with 8% and 16% of celecoxib (CX), was used for sustained release formulations of CX. After optimize condition, the best solvent for electrospinning of PLA system was chloroform/methanol 20% v/v. The morphology of the nanofiers, distribution of the drug inside the nanofiers and possible reactions between polymers and CX in nanofiers were studied by scanning electron microscopy, X-ray diffraction and fourier transform infrared spectroscopy technics. In vitro CX release from the nanofiber mats were evaluated in solution of HCl (pH = 1.5), citrate buffer (pH = 3) and carbonate buffer (pH = 8) by using UV-Vis spectroscopy technic. Drug release was dependent to polymer type, CX percent and release environment. CX release in nanofiber mats of PLA with 8% and 16% w/w of CX, was increased, respectively. Korsemeyer-Peppas release exponent (n) indicates that CX release mechanism was non-Fickian diffusion for formulations of PLA nanofiber mats.