Association of IL-19 gene polymorphism at position -513T/C with risk of H. Pylori

Helicobacter Pylori (H.pylori) is a flagellated, spiral- shaped, microaerophilic gram negative bacterium that colonizes stomach mucosa and causes upper gastrointestinal diseases, such as gastric inflammation, chronic gastric ulcers and gastric Carcinoma. Chronic inflammation plays an important role in the pathogenesis of autoimmune diseases, allergies and cancer. Inflammatory cytokines, such as IL-19 play an important role in the pathogenesis of diseases caused by H. pylori. Since Helicobacter infection is very important and effects many subjects for a long period, and since it has the potential of converting into cancer, we attempted to examine the role of IL-19 cytokine in induction and continuation of this disease. Materialand methods: In this case-control study, blood samples of 100 patient's and 100 healthy individuals was examined for gene polymorphisms of IL-19 at rs1028181-513T/C position in patients with H. pylori infection. Genotype of this polymorphism was determined by RFLP PCR method. Statistical data analysis of genomic and serum studies of patients was carried out by the X 2 (Chi square) and logestic regression. Investigation of relationship between T and C alleles at rs1028181-513T/C position indicated that there is a significant correlation between allele C and H. pylori infection (p = 0.04 OR = 0/66 (CI; 0/45-0.96)). It seems that there is a direct association between Helicobacter Pylori infection, and C allele at rs1028181-513T/C position.