Effect of eight weeks of supplementation of omega-3 supplementation and TRX training on visfatin and insulin resistance in women with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases with hyperinsulinemia in women. Infertility with prevalence of 15% is one of the major problems in the society. Therefore, this study was performed with aim to evaluate the effect of 8 weeks of TRX and omega-3 supplementation on serum visfatin levels and insulin resistance in women with PCOS. This clinical trial study was performed in 2017 on 28 patients with polycystic ovary syndrome in Isfahan. Participants were randomly divided into four groups: TRX training, omega-3 supplementation, exercise-supplementation, and control. The supplement and combination groups received 56 capsules of omega-3 supplement 1 gr (360 mg of EPA and 280 mg of DHA). The exercise and combination groups received an exercise program TRX including 10 minutes warm-up, 45 minutes TRX training and 10 minutes of cool-down. The control group was only followed up without any intervention. Blood samples were taken before and after 8 weeks of intervention to determine the serum levels of visfatin, fasting glucose, insulin and insulin resistance. Data analysis was performed using SPSS software (version 21) and by correlated t-test and variance analysis. P < 0.05 was considered statistically significant. After 8 weeks of intervention, weight loss in the TRX group was significantly higher than that of the supplement and control groups (p <0.05). The difference in mean fasting blood glucose level before and after the intervention was significant in the exercise, supplementation and control groups (p <0.05). Also, the difference in mean of insulin before and after the intervention was significant in the exercise, supplementation and combination groups (p <0.05). The difference in mean of insulin resistance before and after the intervention was significant in all 4 groups (p <0.05). Changes in serum visfatin levels were significant before and after the intervention in the exercise, supplementation and combination groups (p <0.05). Eight weeks of TRX training and the use of omega-3 supplementation due to weight loss and insulin resistance can be effective in controlling and improving the complications of polycystic ovary syndrome in women.