Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice

Inroduction & Objective: Retinoic acid is recognized as regulators of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was conducted to investigate the effect of retinoic acid on the Ovaries and Oviduct Tissue in Female adult BALB/c mice In this study after determination the appropriate dose of retinoic acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg.b.w (Group III) , control group( non- injection) and sham (distilled water injection). ANOVA analysis and Duncan test was used to compare the means with significant level (P˂0.05) and (P˂0.001). During macroscopic examination, significant weight decrease was observed in all three doses (P <0.001) and in microscopic studies, reduction of small and large diameter , number of graph follicles and corpus luteum were observed (P <0.05), (P <0.001).While increasing the number of degenerative follicles and damaged zona pellucidas were significant (P <0.05), (P <0.001) , and reduction in oviduct diameter was significantly higher than the control group, of course, this reduction was not significant. It can generally be concluded that retinoic acid has a deleterious effect on Ovarian and Oviduct Tissue of mice.