The effects of short-term creatine monohydrate supplementation on a single resistance exercise induced-indirect indicators some of cellular damage in male wrestler

Creatine monohydrate as one of the most widely consumed nutritional supplements to increase athletic performance is widely popular among athletes. However, there are recent concerns about some of the adverse effects of short and long term use of creatine on health indices. Therefore this study was conducted to identify the effect of creatine monohydrate loading on total serum cellular damage indices changes (Creatine Kinase & Lactate Dehydrogenase) following one session resistance exercise in male wrestler. Eighteen volunteer collegiate young male wrestlers (aged 21.11±1.13 years, fat 12.67±1.84 %, and BMI 21.96±0.70 kg/m2) in a quasi-experimental, randomized and double-blind design were allocated equally into supplement and placebo groups. After six consecutive days supplementation (300 mg.kg-1.day body weight creatine monohydrate or dextrose), all subjects were participated in a single- session circle resistance exercise protocol (with 80 % 1-RM in 3 sets with 6 repetition) include six station participated. Changesin cellular damage indices were determined in three phases (before and after the supplement phase, 24 hours after the exercise protocol). Data were analyzed by repeated measure ANOVA, Bonferroni and independent t test at α≤0.05. The results show that the creatine loading has only significant effect on the basal total serum CK in supplement group (P<0.05). Moreover, the total serum CK and LDH in both groups (supplement & placebo) were significantly increased 24 hour after the resistance exercise (P<0.05). However, the change range of the cellular damage indices 24 hours in supplement group was insignificantly lower than in placebo group (P>0.05). According to normal variation of total serum Creatine Kinase in the base case and due to the lack of effect of creatine on 24 hours indicators of cellular damage in male wrestler after the resistance exercise, definitive comment in related creatine supplementation induced- cellular damage, more research is needed in the further. Key words: Creatine mon