Outcomes of Gamma Knife Radiosurgery in Patients with Parasagittal ‎Meningioma

Treatment of parasagittal meningioma (PSM) is always a challenge, especially if the tumor is spread enough to invade critical structures like venous sinuses. This study aims to evaluate the outcomes of gamma knife radiosurgery in patients with parasagittal meningioma.

In this descriptive retrospective study, medical records of 61 patients with PSM who had undergone GKRS from 2003 to 2013 were reviewed. The demographic characteristics, medical history and radiotherapy history, tumor's volume and the characteristics of radiosurgery were assessed.  Radiological tumor control following treatment were evaluated during follow-up period.

In this study, 32 patients (52.5%) were men and 29 (47.5%) were women. Of 61 patients, 45 had a history of surgery or/and radiotherapy. The mean tumor volume was 11.35±9.20 ml (1-37.9 ml). The mean follow-up time was 30.28±27.48 months. Five patients died. Radiologic tumor control was achieved in 91.8% of the patients, in whom the tumor volume decreased to 30 (49.2%) and remained unchanged in 26 (42.6%) ones. The tumor volume increased in 5 patients (8.2%). Overall, the progression-free survival of the patients was 98.6% during 12 and 67.04±13.4% during 60 months. Edema occurrence rate was 18%. There was no significant difference in GKRS characteristics, tumor volume, and history of surgery and radiotherapy between patients whose tumors were controlled and patients who experienced an increase in the tumor volume.

Our study suggest that GKRS can be the first or second treatment to control PSM[NM1] . There was no association between the treatment outcome, tumor characteristics, and radiosurgery parameters AS radiosurgery management in PSMs encounter limitations , a long-term follow-up to diagnose life-threatening complications including brain edema is needed.




 [NM1]It is not a conclusion statement, but it can be suggest.