~
Correlation between IgE and Histamine and Pulp Polyp

Among different diseases of dental pulp, less attention has been paid to the immunopathogenesis of pulp polyp. So the aim of this study was to evaluate the relationship between pulp polyp formation and allergy. Methods & Materials: For this purpose, thirty - three samples including 17 pulp polyps and 16 normal pulps were gathered. After a 3-day incubation period, sandwich and competitive ELISA techniques were used to assess the presence and concentration of IgE and histamine, respectively. IgE was found in 100% of pulp polyps and 50% of normal pulps, with concentrations of 0.7615±0.4858 and 0.1927±0.2193. Histamine was found in 100% of polyps and 12.5% of normal pulps, with concentrations of 30.8353±34.1531 and 3.125±8.732. The two groups showed statistically significant differences in terms of both the concentration and presence of IgE and histamine. There was also a significant statistical correlation between the concentration of IgE and histamine in the two groups. We could suugest possible role for type I hypersensitivity reaction or allergy in the pathogenesis of pulp polyp.