Electrochemiluminescence Sensor Based on Ru(bpy)32+-Eu2(CO3)3 nanoparticle-chitosan Modified Electrode for the Ultrasensitive Detection of Dextromethorphan HBr

Nowadays electrochemiluminescence (ECL) has shown considerable growth as a stage for analytical procedures in numerous areas such as pharmaceutical analysis, immunoassay, DNA analysis as well as clinical analysis. Herein, a novel ECL sensor was fabricated for ultrasensitive detection of Dextromethorphan HBr (DXM HBr) based on Ru(bpy)32+/Eu2(CO3)3 nanoparticle/chitosan composite. The electrochemical and ECL performance of the suggested sensor were examined. Under the optimal conditions, the constructed DXM HBr sensor showed a wide linear range from 1.0×10-12 to 1.0×10-8 mol.L-1 with a detection limit of 7.4×10-13 mol.L-1 (at signal-to-noise ratio of 3) and relative standard deviation of 3.7%. Furthermore, the demonstrated ideal stability and sensitivity was found for the ECL sensor which might be contributed to the high surface area and the good electrical conductivity of Eu2(CO3)3 NPs. In addition, the ECL sensor was used to detect DXM HBr in human serum samples and displayed desirable results.