The glucose metabolism disorder and dyslipidemia among girls with different phenotype polycystic ovary syndrome

This study aimed to determine the prevalence of glucose metabolism disorder and dyslipidemia in 14–18‑year‑old girls with different phenotype polycystic ovary syndrome (PCOS).

This descriptive, cross‑sectional study was conducted on 3200 high‑school adolescents aged 14–18 years in Shiraz in 2010.  Selected parameters of metabolic syndrome (fasting blood glucose, glucose tolerance test [GTT], insulin level, triglyceride (TG), cholesterol, and high‑density lipoprotein [HDL]), based on adult treatment panel Ш definition criteria, were compared between the “PCOS” and control groups.

Results were compared at four main phenotypes. The level of serum TG was increased in the Phenotype B (P = 0.03) and Phenotype D (P = 0.01), compared to the control group. Cholesterol and low‑density lipoprotein levels (P < 0.05) and GTT (P > 0.05) were increased, and HDL was decreased (was below 50) in all the four phenotypes and the control group (P > 0.05).

The risk of metabolic alterations of glucose metabolism disorder and dyslipidemia in PCOS adolescents was more than non‑PCOS counterparts.