Green synthesis and evaluation of 5-(4-aminophenyl)-4-aryl-4H-1, 2, 4-triazole-3-thiol derivatives
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol was achieved in four steps, In first step, 4-amino benzoic acid refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II refluxed in ethanolic potassium hydroxide with carbon disulfide to produce 5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol III. Compound III refluxed in ethanol with different substituted primary aryl amine gave title compounds 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol IVa-o. The compounds obtained were identified by FT-IR, 1H-NMR, GC- mass spectroscopy data, and elemental analysis and also screened for in-vivo antimicrobial activity. In vitro antibacterial activity was carried out against organisms like E.coli. K.pneumonia, S.aureus, and B.subtilis as well as in vitro antifungal activity were carried out against organisms like A.niger and S.cerevisiae. In vitro antimicrobial evaluation, the most potent broad spectrum compound IVc, IVd and IVf were found significant agent against standard drug Norfloxacin and Ketoconazole.
Language:
English
Published:
Iranian Journal of Pharmaceutical Sciences, Volume:13 Issue: 2, Spring 2017
Pages:
37 to 50
magiran.com/p2121795
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!