Study the protective effect of hydroalcoholic extract of Satureja avromanica on the glycogen and lipid storage in liver of type 2 diabetic male rats

Impairment in metabolism of lipids, especially in liver tissue, is one of the main complications of type 2 diabetes (T2D). This study aimed to evaluate the effect of hydroalcoholic extract of Satureja avromanica (HESA) on glycogen and lipid content in liver tissue of male rats with type 2 diabetes. 

In this experimental study, Twenty-four male Wistar rats were divided into 4 groups (n=6) including: controls and T2D groups treated with or without hydroalcoholic extract of Satureja avromanica extract (50 mg/kg). After 60 days of treatment lipid and glycogen storage of liver were measured. The data collected after entering SPSS software version 16 were analyzed using one-way analysis of variance.

The results showed that in the diabetic group treated with Satureja avromanica extract, weight was significantly higher and the fasting blood sugar was significantly lower than the diabetic control group (P<0.01). Also, in relation to liver tissue, in the diabetic group receiving the extract of Satureja avromanica, glycogen storage is significantly higher and the levels of cholesterol and triglyceride is significantly lower than the diabetic control group (P<0.05).

This study showed that hydroalcoholic extract of Satureja avromanica can have anti-diabetic effects on the liver tissue in diabetic rats.