Dietary Total Antioxidant Capacity and Risk of Non-Alcoholic Fatty Liver Disease: A Case‐Control Study

Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. This study aimed to assess whether a relationship exists between dietary total antioxidant capacity (TAC) and the odds of NAFLD. Study design: A case-control study.

In this age‐and sex‐matched case‐control study in 2019, patients with NAFLD and healthy controls were recruited from a hospital clinic. All participants completed a validated 168‐item food frequency questionnaire, the results of which were subsequently used to generate dietary TAC. Oxygen radical absorbance capacity values were used to calculate dietary TAC.

Altogether, 225 patients with NAFLD and 450 healthy controls were enrolled. Participants with NAFLD had a higher mean weight, BMI, energy (P<0.050), and lower physical activity and DTAC scores (P<0.050) than the control group. In an adjusted model, participants who were in the highest quartile of dietary TAC had a lower risk of NAFLD (odds ratio 0.78, 95% CI: 0.67, 0.91).

A high DTAC was related to a decreased risk of NAFLD. Suggest the intake of a diet with high antioxidant capacity is significant at preventing NAFLD. Increasingly itemized investigations in design of randomized control trials require to reveal more insight into these results.