Effect of 6 weeks high intensity interval training on selected factors of caadiac angiogenesis in rats with myocardial infarction

Aim myocardial infarction(MI) is destruction and cell Death in part of the myocardial that it Happens During an Ischemia. Evidence suggests that exercise training Increased capillary density in Skeletal and myocardial muscles presumably. But Cell process In response to activity and appropriate Intensity is not clear. Vascular endothelial growth factor(VEGF) and endostatin and also their common receptor(FLT-1) are the most important factors involved in angiogenesis. Methodology in this study we investigated the effect of 6 weeks of high intensity interval training on changes of these factors in 12 male Wistar rats with 10-week old with myocardial infarction in two groups, experimental(60 minutes interval running on treadmill, 4 minutes running with 85-90% of VO2max , and 2 minutes recovery with 50-60% VO2max and four days a week per six weeks) and control(no exercise). Result The results show a positive and significant increase in FLT-1 and VEGF and no significant changes in collagen 18 gene expression during HIIT training. Conclusion Overall its results conforms that HIIT training can effective on angiogenesis factors after MI.