In vitro evaluation of the effect of ethanolic extract of Phyllanthus emblica L. on human coagulation indices

Amla (Phyllanthus emblica L.) is a member of the Phyllanthaceae family and grows widely in the tropics of China, India, Indonesia, and the Malay Peninsula and is used in many traditional medicinal systems such as Chinese medicine and Indian Ayurveda. Its fruit is one of the richest natural sources of vitamin C and is a bleeding stopper and also very useful in the treatment of hemorrhoids. Different parts of this plant show anti-diabetic, antibacterial, antioxidant, and hepatoprotective properties. Chemical researches on Amla fruit indicate its high nutritional value. This study aimed at in vitro evaluating the effect of ethanolic extract of this plant on human coagulation indices. Different concentrations of the whole Amla plant extract were prepared, and its effect on coagulation indices including prothrombin time (PT), activated partial thromboplastin time (aPTT), and clotting time (CT) were evaluated, and the results were analyzed by t-test. The results showed that Amla ethanolic extract reduced aPTT and CT, but it had no significant effect on PT indices. The findings of this study indicate the coagulant effect of Amla ethanolic extract; however, further studies on animal and human models seem necessary.