The Effect of 8 Weeks of Resistance Training with Taurine Supplementation on Fasting Glucose, Insulin Resistance, and GLUT4 in Soleus Muscle Tissue in Male Wistar Rats with Type 2 Diabetes

Type 2 diabetes is a metabolic disorder. Recently, some studies have shown that the amino acid taurine may be effective in preventing and improving the effects of some metabolic diseases. This study aims to determine the effect of resistance training with taurine supplementation on fasting glucose, insulin resistance, and GLUT4 in soleus muscle tissue of type2 diabetic mice.

In this experimental study, forty male Wistar rats, weighing 215 to 230 g, were randomly divided into 5 groups of 8: healthy control, diabetic control, taurine, resistance training, and resistance training with taurine. HFD-STZ (High Fat Diet-Streptozotocin) method was used to induce type 2 diabetes. Resistance training was performed 5 sessions per week for 8 weeks, with an intensity of 30% to 100% of body weight. 250 mg of taurine per kg of body weight was used in two groups of taurine and exercise with taurine. One-way analysis of variance was used in the research.

Induction of diabetes resulted in decreased (GLUT4), increased glucose, and insulin resistance in diabetic specimens. 8 weeks of resistance training, taurine supplementation, and resistance training with taurine caused a significant reduction in fasting glucose (F=2896.90, p=0.4040), insulin resistance (F=1471.43, p=0.0010), and an increase in GLUT4 content (F=1936.18, p=0.0020). There was no significant difference in the changes between the two diabetic groups of exercise and taurine. However, the exercise group with taurine had a significant difference in the rate of change compared to the other two experimental groups.

Combining exercise with taurine (for 8 weeks) can have beneficial effects on the variables of this study in patients with type 2 diabetes.