Determination of parameters of Fung hyperelastic model for intracranial blood vessel of human using biaxial tensile test

Understanding of mechanical properties of healthy brain arteries is a key element in the development of clinical diagnosis and prevention.For this reason we make biaxial measurements to have appropriate parameters for the underlying material models. To acquire these properties, eight samples were obtained from middle cerebral arteries of human cadavers, whose death were not due to injuries or diseases of cerebral vessels, and tested within twelve hours after resection. The changes of force and deformation until the vessel rupture were recorded. Thereafter, the stress-strain curves were plotted and fitted with a hyperelastic five-parameter Fung model parameters, according to the best fit, were determined. It was found that the arteries were remarkably stiffer in circumferential than in axial direction. It was also found that the use of multi-parameter hyperelastic constitutive models is applicable for mathematical description of behavior of cerebral vessel tissue. The reported material properties can be a proper reference for numerical simulation of cerebral arteries of healthy or diseased intracranial arteries.