Correlation Between Interleukin 19 Gene Polymorphisms (rs2243191 T/C and Rs1028181-513T/C) and Recurrent Vulvovaginal Candidiasis

Vaginal candidiasis infection is the second most common disease after bacterial vaginitis, affecting about 75% of women at least once in their lifetime. 85 to 90% of these infections are caused by Candida albicans species. Various factors, including genetic and immunology factors, play an important role in the development of this disease . Interleukin 19 is one of the important cytokines in the immune system and has several polymorphisms in the promoter region. The aim of the present study was to determine the association between IL-19 gene polymorphisms (rs2243191 and rs1028181) and recurrent candidiasis vulvovaginitis.

The present case-control study was performed on 100 patients with recurrent vaginal candidiasis and 110 healthy individuals during 2016-2019. Five mL venous blood was taken from each participant and transferred to a tube containing EDTA anticoagulant. Genomic DNA was isolated using a special kit; the PCR chain reaction was performed by ARMS method and data were analysed in patients and control subjects using Chi square test and SPSS software.

The results of the present study revealed that no significant difference was seen in frequency of GG, AG and AA genotypes in the position of both rs2243191 and rs1028181 IL-19 gene in both patients and the control group (P> 0.05). Also, no significant difference was observed in frequency of both A and G alleles in the mentioned positions between patients and the control group (P> 0.05).

No significant association between IL-19 gene polymorphism at positions (rs2243191 T / C and rs1028181-513T / C) and recurrent vulvovaginal candidiasis was observed.