The effect of eight weeks of intense and continuous intermittent training on GDF15 and IL6 factor levels in overweight men

Exercise seems to be effective on factors associated with diseases such as obesity, diabetes or cardiovascular disease. This study aimed to investigate the effect of eight weeks of high intensity interval and continuous training on GDF15 and IL6 in overweight men.

The present study is a semi-experimental study with a pretest-posttest design with a control group. For this purpose, 36 overweight young people in Ahar were selected as a sample and randomly divided into Intense Intensity Exercise (HIIT), Continuous Exercise (MICT) and Control. The training protocol was performed three days a week for eight weeks. 48 hours before the first training session, blood samples were taken from 5 cc of the brachial artery to assess the levels of GDF15 and interleukin 6 by ELISA. The post-test was repeated exactly with the pre-test conditions. The collected data were analyzed by SPSS software version 20 using analysis of covariance.

The results showed that the mean of IL6 was significantly different between the groups (P = 0.029) so that the mean of IL-6 in the control group was significantly higher than the other two groups and in the HIIT group was significantly higher than the MICT group. Another result is the lack of significant difference in mean GDF15 between the three groups.

The results of this study showed that performing HIIT and MICT exercises can improve the cardiovascular status of overweight people by changing the factors affecting cardiovascular conditions such as GDF-15 and IL-6. There is no difference in the use of the two exercises, also.