Evaluation Dexmedetomidine effects on serum antioxidants level

Many studies have shown the effect of dexmedetomidine in decreasimg the levels of reactive oxygen species (ROS) and increasing the endogenous antioxidants. Our goal was to determine the effect of dexmedetomidine on the serum levels of several endogenous antioxidants following spinal surgeries. Forty patients were allocated into two groups: control and intervention. Both groups underwent the same general anesthesia process except the dexmedetomidine infusion in the intervention groupversus normal saline in control group (blinding). Blood samples were drawn before induction and after surgery in recovery roomand levels of Gluthatione peroxidase, catalase and super oxide dismutase were assessed. Superoxide dismutase and catalase levels did not change significantly but glutathione peroxidase levels after the surgery was meaningfully higher than the preoperative measures in both groups. Depite observed differences in the mean of antioxidant levels between the groups, this diversity was not statistically meaningful.