Antibiotic susceptibility pattern of coagulase negative Staphylococci isolated from urinary tract infection in Gonabad

Urinary tract infection is one of the most common bacterial infections and coagulase negative staphylococci are a common cause of this disease based on some reports. Due to increasing the resistance resulting from antibiotics consumption, this study was performed to determine the antibiotic resistance pattern of the coagulase negative staphylococci isolated from urinary tract infections in Gonabad, Iran.

This cross-sectional study was performed on 264 coagulase negative staphylococci isolated from patients who were referred to Jahad Daneshgahi Laboratory due to urinary tract infection in Gonabad city. Identification of bacterial strain was performed by classical identification methods and antimicrobial susceptibility testing was carried out on Mueller-Hinton agar (merck-Germany) using disk diffusion (Kirby Bauer›s) technique.

Out of 264 isolates, the most frequent species of coagulase negative staphylococci (CNS) isolates were Staphylococci epidermidis (84%) followed by Staphylococcus saprophyticus (14%). Based on antibiotic resistance pattern,››Penicillin›› (56.43%) showed the highest resistance followed by "erythromycin" (46.21%), and "nitrofurantion" (42.42%) in order. However, CNS showed the highest susceptibility to "ciprofloxacin" (82.57%), "vancomycin" (78.03%) and "Amikacin" (74.24%).

The findings showed that the use of ciprofloxacin and vancomycin, as the first choice in empirical treatment of Urinary Tract Infection (UTI) in the region, should be reconsidered.