Effect of 8 weeks of continuous running on serum levels of Meteorine like protein and Interleukin-6 in male rats with syndrome metabolic

Controlling obesity can be considered as important part of public health; and physical exercise is recommended as an essential intervention for modulate obesity. The aim of this study was to investigate the effect of 8 weeks of continuous running on serum concentrations of Meteorine like protein and Interlukin-6 (IL-6) in male rats with metabolic syndrome.

The present was an experimental study. 24 Wistar male rats, with age 6 weeks old and weight 150-180 gr randomly divided into two groups including standard diet (SD, n=8) and high fat diet (HFD, n=16). They were then placed on a pre-exercise diet for 12 weeks. After this period, 8 rats from each groups of SD and HFD were selected to determine syndrome metabolic state through lipid profile and Insulin serum content measurements. Moreover, 16 rats from HDF group were divided randomly into two groups including metabolic syndrome control (Ctr+MetS, n=8) and continuous running (CT, n=8). The aerobic continuous running protocol, included 65-75% of maximum speed performed from week 1 to 8 At the end of intervention, serum levels of Meteorine like protein and IL-6 were assessed through specific rats ZellBio kits. One way ANOVA and Tukey post hoc tests were used to determine mean differences between groups. Data were analyzed using SPSS version 20 and the significance level was set as p≤0.05.

Eight weeks of continuous running didn’t indicate any significant effect (insignificant increase) on serum meteorine level (p=0.09) but showed a significant increase on interleukin 6 in metabolic syndrome group (p=0.001).

It seems that 8 weeks of continuous running have a little impact on inflammation induced obesity through modulating of meteorine-like protein and IL-6.