THE APPLICATION OF AMNIOTIC FLUID-DERIVED MESENCHYMAL STEM CELL-CONDITIONED MEDIUM IN CANCER TREATMENT

Currently, chemotherapy and surgery are the main strategies in the clinical treatment of cancer. However, the side effects of chemotherapy drugs on normal tissues affect the quality of a patient’s life. In addition, the resistance of the cancer cells to anticancer drugs limits the therapeutic effects. Therefore, the discovery of new treatments to improve cancer therapy is required. In recent years, many studies have shown the potential inhibitory effects of mesenchymal stem cells in cancer progression. Human amniotic fluid mesenchymal stem cells (hAFMSCs) are the unique type of human mesenchymal stem cells that are suitable for some human diseases. Furthermore, recently there are investigations on the anticancer effects of these types of cells. Conditioned medium of mesenchymal stem cells has more advantages than stem cells, such as being easy to produce, package, freeze, and transport, which can lead to drug production. As a result, the conditioned media of amniotic fluid mesenchymal stem cells can be a beneficial candidate for cancer treatment.