Synthesis and Study Impaction Antibacterial, Antifungal Activity Newly Pyridazine and 1,2,4-Triazine Derivatives
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
In this research study, the synthesis sequence of novel pyridazine and 1,2,4-Triazine derivatives was determined by reacting α-hydrazino-N-Carbazole acetamide (1) with acid anhydride derivatives used glacial acetic acid as a solvent to prepare compounds (2-9) pyridazine derivatives reacted compound (1) with phenyl isocyanate, phenyl thioisocyanate, and α-naphthyl isocyanate to use absolute ethanol as solvent to give compounds (10-12). Compounds (10-12) were condensed with (2N. NaOH) to give compounds (14-16) to denominate 1,2,4-Triazine derivatives. Reacted compound (1) with CS2/KOH used absolute ethanol as solvent to provide potassium salt (13). This salt reacts with 95% hydrazine hydrate to give compound (17). The newly synthesized compounds were tested against different microorganisms to evaluate their antimicrobial activities on bacterial strains, gram-positive bacteria, gram-negative bacteria, and fungal strains to identify the most efficient biologically active compounds.
Keywords:
Carbazole , Pyridazine , 1 , 2 , 4-Triazine , anti-microbial
Language:
English
Published:
Chemical Methodologies, Volume:6 Issue: 4, Apr 2022
Pages:
269 to 279
magiran.com/p2417656
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!