Effect of tafluprost eye drop on intra ocular pressure (IOP) and pupil diameter (PD) in the healthy horses

Tafluprost is an analogue of PGF2α that reduce the IOP by prostoglandian receptors and increase ocular fluid outflow. The aim of this study was evaluatation of tafluprost effect on IOP in normal horse eye.

fourteen healthy adult female cross-breed (Turkmen-Thoroughbred) horses were used in this study( 3.5 - 10 years old). The horses were randomly devided into two groups. In group A, seven horses received one drop of 0.0015% preservative-free tafluprost (Zioptan®, Akron, Oak pharmaceutical Inc, France) in right eye. In group B, seven horses received one drop of sterile eye drop as placebo(Tearlose®, Sina Darou Laboratories Company, Tehran, Iran) in right eye. IOP and PD was measured by respectively rebound tonometer ( TonoVet®, Finland) and Caliper device ( China) at the baseline , 30 , 60 , 120 ,240 min, 24 and 48 h post instillation.

Tafluprost has significant IOP reduction at 30, 60, 120, 240 min, 24 and 48 h after drug administration in treated group. Descriptive statistics revealed that mean IOP decrease in treated eyes from 22±5.4 mmHg to 16.6±1.6 mmHg during 48 hours. Also, the mean PD in treated group at 30, 60, 120 and 240 minutes was significantly lower than the baseline time. there is a significant relationship between drug administration and time (P = 0.0001).

Descriptive statistics revealed that mean PD decrease in treated eyes during 48 hours post instillation from 17.9±2.3 mm to 18.2±3.3 mm.