Different ways to enhance the permeability, lipophilicity, and bioavailability of the antidiabetic drug, Metformin: Review Article

Metformin is a drug that needs improvement in its bioavailability and absorption. This can be acheived by using different drug delivery systems, making prodrugs, and changing the drug release en- vironment. Drug delivery systems are used for various reasons, for example, targeted drug delivery, pro- tecting the drugs from destruction by enzymes, and enhancing the drug's absorption, permeability, and bioavailability. According to the studies and surveys, the permeability, absorption, and bioavailability of metformin can be improved in many ways, like making prodrugs and using carriers. Prodrugs and lipid- based carriers like nanostructured lipid carriers and lipid-based polymers are the best methods that can help the medical system to reduce the dose of metformin usage in patients and reduce the side effects.